Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

The use of peptides as therapeutic agents is undergoing a renaissance with the expectation of new drugs with enhanced levels of efficacy and safety. Their clinical potential will be only fully realised once their physicochemical and pharmacokinetic properties have been precisely controlled. Here we...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Ouberai, Myriam M., Dos Santos, Ana L. Gomes, Kinna, Sonja, Madalli, Shimona, Hornigold, David C., Baker, David, Naylor, Jacqueline, Sheldrake, Laura, Corkill, Dominic J., Hood, John, Vicini, Paolo, Uddin, Shahid, Bishop, Steven, Varley, Paul G., Welland, Mark E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647335/
https://ncbi.nlm.nih.gov/pubmed/29044101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01114-1
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