Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

The use of peptides as therapeutic agents is undergoing a renaissance with the expectation of new drugs with enhanced levels of efficacy and safety. Their clinical potential will be only fully realised once their physicochemical and pharmacokinetic properties have been precisely controlled. Here we...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Ouberai, Myriam M., Dos Santos, Ana L. Gomes, Kinna, Sonja, Madalli, Shimona, Hornigold, David C., Baker, David, Naylor, Jacqueline, Sheldrake, Laura, Corkill, Dominic J., Hood, John, Vicini, Paolo, Uddin, Shahid, Bishop, Steven, Varley, Paul G., Welland, Mark E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647335/
https://ncbi.nlm.nih.gov/pubmed/29044101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01114-1
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