Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

Posterior fossa ependymomas (EPN_PF) in children comprise two morphologically identical, but biologically distinct tumor entities. Group-A (EPN_PFA) tumors have a poor prognosis and require intensive therapy. In contrast, group-B tumors (EPN_PFB) exhibit excellent prognosis and the current consensus...

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Publicado no:Acta Neuropathol
Main Authors: Panwalkar, Pooja, Clark, Jonathan, Ramaswamy, Vijay, Hawes, Debra, Yang, Fusheng, Dunham, Christopher, Yip, Stephen, Hukin, Juliette, Sun, Yilun, Schipper, Matthew J., Chavez, Lukas, Margol, Ashley, Pekmezci, Melike, Chung, Chan, Banda, Adam, Bayliss, Jill M., Curry, Sarah J., Santi, Mariarita, Rodriguez, Fausto J., Snuderl, Matija, Karajannis, Matthias A., Saratsis, Amanda M., Horbinski, Craig M., Carret, Anne-Sophie, Wilson, Beverly, Johnston, Donna, Lafay-Cousin, Lucie, Zelcer, Shayna, Eisenstat, David, Silva, Marianna, Scheinemann, Katrin, Jabado, Nada, McNeely, P. Daniel, Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Hawkins, Cynthia, Korshunov, Andrey, Judkins, Alexander R., Venneti, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647236/
https://ncbi.nlm.nih.gov/pubmed/28733933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1752-4
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