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Thwarting endogenous stress: BRCA protects against aldehyde toxicity

Homologous recombination (HR) and the Fanconi Anemia (FA) pathways constitute essential repair pathways for DNA damage, which includes DNA double‐stranded breaks (DSB) and inter‐strand cross‐links (ICL), respectively. Germline mutations affecting a single copy of the HR factors BRCA1 and BRCA2 predi...

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Publicat a:EMBO Mol Med
Autors principals: Ray Chaudhuri, Arnab, Nussenzweig, André
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623899/
https://ncbi.nlm.nih.gov/pubmed/28835508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708194
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