BLM and SLX4 play opposing roles in recombination‐dependent replication at human telomeres

Alternative lengthening of telomeres (ALT) is a telomere lengthening pathway that predominates in aggressive tumors of mesenchymal origin; however, the underlying mechanism of telomere synthesis is not fully understood. Here, we show that the BLM–TOP3A–RMI (BTR) dissolvase complex is required for AL...

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Veröffentlicht in:EMBO J
Hauptverfasser: Sobinoff, Alexander P, Allen, Joshua AM, Neumann, Axel A, Yang, Sile F, Walsh, Monica E, Henson, Jeremy D, Reddel, Roger R, Pickett, Hilda A
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623873/
https://ncbi.nlm.nih.gov/pubmed/28877996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796889
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