APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel K(V)10.1

The human ether-à-go-go channel (hEag1 or K(V)10.1) is a cancer-relevant voltage-gated potassium channel that is overexpressed in a majority of human tumors. Peptides that are able to selectively inhibit this channel can be lead compounds in the search for new anticancer drugs. Here, we report the a...

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Vydáno v:Mar Drugs
Hlavní autoři: Moreels, Lien, Peigneur, Steve, Galan, Diogo T., De Pauw, Edwin, Béress, Lászlo, Waelkens, Etienne, Pardo, Luis A., Quinton, Loïc, Tytgat, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618426/
https://ncbi.nlm.nih.gov/pubmed/28902151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md15090287
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