Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart

Legumain (EC 3.4.22.34) is an asparaginyl endopeptidase. Legumain activity has been detected in various mouse tissues including the kidney, spleen and epididymis. Legumain is overexpressed in the majority of human solid tumors and transcription of the legumain gene is regulated by the p53 tumor supp...

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Bibliographic Details
Published in:Biochem Biophys Rep
Main Authors: Yamane, Takuya, Kozuka, Miyuki, Yamamoto, Yoshio, Nakano, Yoshihisa, Nakagaki, Takenori, Ohkubo, Iwao, Ariga, Hiroyoshi
Format: Artigo
Language:Inglês
Published: Elsevier 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614579/
https://ncbi.nlm.nih.gov/pubmed/28956004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.12.010
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