HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis

Leishmania donovani is known to induce myelopoiesis and to dramatically increase extramedullary myelopoiesis. This results in splenomegaly, which is then accompanied by disruption of the splenic microarchitecture, a chronic inflammatory environment, and immunosuppression. Chronically inflamed tissue...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Hammami, Akil, Abidin, Belma Melda, Charpentier, Tania, Fabié, Aymeric, Duguay, Annie-Pier, Heinonen, Krista M., Stäger, Simona
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608422/
https://ncbi.nlm.nih.gov/pubmed/28892492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006616
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