HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis

Leishmania donovani is known to induce myelopoiesis and to dramatically increase extramedullary myelopoiesis. This results in splenomegaly, which is then accompanied by disruption of the splenic microarchitecture, a chronic inflammatory environment, and immunosuppression. Chronically inflamed tissue...

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Publicat a:PLoS Pathog
Autors principals: Hammami, Akil, Abidin, Belma Melda, Charpentier, Tania, Fabié, Aymeric, Duguay, Annie-Pier, Heinonen, Krista M., Stäger, Simona
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608422/
https://ncbi.nlm.nih.gov/pubmed/28892492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006616
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