Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

O-glycosylation of the Plasmodium sporozoite surface proteins CSP and TRAP was recently identified, but the role of this modification in the parasite life cycle and its relevance to vaccine design remain unclear. Here, we identify the Plasmodium protein O-fucosyltransferase (POFUT2) responsible for...

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Publicado no:Nat Commun
Main Authors: Lopaticki, Sash, Yang, Annie S. P., John, Alan, Scott, Nichollas E., Lingford, James P., O’Neill, Matthew T., Erickson, Sara M., McKenzie, Nicole C., Jennison, Charlie, Whitehead, Lachlan W., Douglas, Donna N., Kneteman, Norman M., Goddard-Borger, Ethan D., Boddey, Justin A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601480/
https://ncbi.nlm.nih.gov/pubmed/28916755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00571-y
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