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Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

O-glycosylation of the Plasmodium sporozoite surface proteins CSP and TRAP was recently identified, but the role of this modification in the parasite life cycle and its relevance to vaccine design remain unclear. Here, we identify the Plasmodium protein O-fucosyltransferase (POFUT2) responsible for...

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Publicat a:Nat Commun
Autors principals: Lopaticki, Sash, Yang, Annie S. P., John, Alan, Scott, Nichollas E., Lingford, James P., O’Neill, Matthew T., Erickson, Sara M., McKenzie, Nicole C., Jennison, Charlie, Whitehead, Lachlan W., Douglas, Donna N., Kneteman, Norman M., Goddard-Borger, Ethan D., Boddey, Justin A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601480/
https://ncbi.nlm.nih.gov/pubmed/28916755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00571-y
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