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Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy

In diabetes, matrix metalloproteinase-9 (MMP-9) is activated, which damages mitochondria, resulting in accelerated capillary cell apoptosis. Regulation of MMP-9 is controlled by multiple transcription factors including nuclear factor-kB (NF-kB) and activator protein-1 (AP-1). Binding of these transc...

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Detalles Bibliográficos
Publicado en:Biochim Biophys Acta
Main Authors: Mishra, Manish, Kowluru, Renu A.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599300/
https://ncbi.nlm.nih.gov/pubmed/28478229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2017.04.024
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