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Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy
In diabetes, matrix metalloproteinase-9 (MMP-9) is activated, which damages mitochondria, resulting in accelerated capillary cell apoptosis. Regulation of MMP-9 is controlled by multiple transcription factors including nuclear factor-kB (NF-kB) and activator protein-1 (AP-1). Binding of these transc...
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| Published in: | Biochim Biophys Acta |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5599300/ https://ncbi.nlm.nih.gov/pubmed/28478229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2017.04.024 |
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