P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment

Cellular senescence is characterized by permanent cell cycle arrest, triggered by a variety of stresses, such as telomerase inhibition, and it is recognized as a tumor-suppressor mechanism. In recent years, telomerase has become an important therapeutic target in several cancers; inhibition of telom...

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Опубликовано в: :Cell Death Dis
Главные авторы: Chen, Rong-Jane, Wu, Pei-Hsuan, Ho, Chi-Tang, Way, Tzong-Der, Pan, Min-Hsiung, Chen, Hsiu-Min, Ho, Yuan-Soon, Wang, Ying-Jan
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596539/
https://ncbi.nlm.nih.gov/pubmed/28796247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.333
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