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A P-Tether-Mediated, Iterative S(N)2’-Cuprate Alkylation Strategy to Skipped Polyol Stereotetrads: Utility of an Oxidative “Function Switch” with Phosphite-Borane Tethers

The development of a P-tether-mediated, iterative S(N)2’-cuprate alkylation protocol for the formation of 1,3-skipped polyol stereotetrads is reported. This two-directional synthetic strategy builds molecular complexity from simple, readily prepared C(2)-symmetric dienediols and unites the chemistry...

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Bibliografische gegevens
Gepubliceerd in:Org Lett
Hoofdauteurs: Markley, Jana L., Hanson, Paul R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595703/
https://ncbi.nlm.nih.gov/pubmed/28471180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b00852
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