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A de novo substructure generation algorithm for identifying the privileged chemical fragments of liver X receptorβ agonists
Liver X receptorβ (LXRβ) is a promising therapeutic target for lipid disorders, atherosclerosis, chronic inflammation, autoimmunity, cancer and neurodegenerative diseases. Druggable LXRβ agonists have been explored over the past decades. However, the pocket of LXRβ ligand-binding domain (LBD) is too...
Uloženo v:
| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5593923/ https://ncbi.nlm.nih.gov/pubmed/28894088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08848-4 |
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