Zoledronic acid inhibits NFAT and IL-2 signaling pathways in regulatory T cells and diminishes their suppressive function in patients with metastatic cancer

Regulatory T cells (Treg) suppress anti-tumor immune responses and their infiltration in the tumor microenvironment is associated with inferior prognosis in cancer patients. Thus, in order to enhance anti-tumor immune responses, selective depletion of Treg is highly desired. We found that treatment...

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Veröffentlicht in:Oncoimmunology
Hauptverfasser: Sarhan, Dhifaf, Leijonhufvud, Caroline, Murray, Shannon, Witt, Kristina, Seitz, Christina, Wallerius, Majken, Xie, Hanjing, Ullén, Anders, Harmenberg, Ulrika, Lidbrink, Elisabet, Rolny, Charlotte, Andersson, John, Lundqvist, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593706/
https://ncbi.nlm.nih.gov/pubmed/28920001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1338238
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