BTK suppresses myeloma cellular senescence through activating AKT/P27/Rb signaling

We previously explored the role of BTK in maintaining multiple myeloma stem cells (MMSCs) self-renewal and drug-resistance. Here we investigated the elevation of BTK suppressing MM cellular senescence, a state of irreversible cellular growth arrest. We firstly discovered that an increased expression...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Gu, Chunyan, Peng, Hailin, Lu, Yue, Yang, Hongbao, Tian, Zhidan, Yin, Gang, Zhang, Wen, Lu, Sicheng, Zhang, Yi, Yang, Ye
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593608/
https://ncbi.nlm.nih.gov/pubmed/28915637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18096
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