Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach

Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painfu...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Beccari, Andrea R., Gemei, Marica, Lo Monte, Matteo, Menegatti, Nazareno, Fanton, Marco, Pedretti, Alessandro, Bovolenta, Silvia, Nucci, Cinzia, Molteni, Angela, Rossignoli, Andrea, Brandolini, Laura, Taddei, Alessandro, Za, Lorena, Liberati, Chiara, Vistoli, Giulio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591244/
https://ncbi.nlm.nih.gov/pubmed/28887460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11194-0
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