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Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach

Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painfu...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Beccari, Andrea R., Gemei, Marica, Lo Monte, Matteo, Menegatti, Nazareno, Fanton, Marco, Pedretti, Alessandro, Bovolenta, Silvia, Nucci, Cinzia, Molteni, Angela, Rossignoli, Andrea, Brandolini, Laura, Taddei, Alessandro, Za, Lorena, Liberati, Chiara, Vistoli, Giulio
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591244/
https://ncbi.nlm.nih.gov/pubmed/28887460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11194-0
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