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Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach
Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painfu...
Shranjeno v:
izdano v: | Sci Rep |
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Main Authors: | , , , , , , , , , , , , , , |
Format: | Artigo |
Jezik: | Inglês |
Izdano: |
Nature Publishing Group UK
2017
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5591244/ https://ncbi.nlm.nih.gov/pubmed/28887460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11194-0 |
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