Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach

Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painfu...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Beccari, Andrea R., Gemei, Marica, Lo Monte, Matteo, Menegatti, Nazareno, Fanton, Marco, Pedretti, Alessandro, Bovolenta, Silvia, Nucci, Cinzia, Molteni, Angela, Rossignoli, Andrea, Brandolini, Laura, Taddei, Alessandro, Za, Lorena, Liberati, Chiara, Vistoli, Giulio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591244/
https://ncbi.nlm.nih.gov/pubmed/28887460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11194-0
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