Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach

Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painfu...

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Publicat a:Sci Rep
Autors principals: Beccari, Andrea R., Gemei, Marica, Lo Monte, Matteo, Menegatti, Nazareno, Fanton, Marco, Pedretti, Alessandro, Bovolenta, Silvia, Nucci, Cinzia, Molteni, Angela, Rossignoli, Andrea, Brandolini, Laura, Taddei, Alessandro, Za, Lorena, Liberati, Chiara, Vistoli, Giulio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591244/
https://ncbi.nlm.nih.gov/pubmed/28887460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11194-0
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