The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

Controlling cholesterol levels is a major challenge in human health, since hypercholesterolemia can lead to serious cardiovascular disease. Drugs that target carbohydrate metabolism can also modify lipid metabolism and hence cholesterol plasma levels. In this sense, dichloroacetate (DCA), a pyruvate...

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Publicado en:Sci Rep
Main Authors: Khan, Abrar Ul Haq, Allende-Vega, Nerea, Gitenay, Delphine, Gerbal-Chaloin, Sabine, Gondeau, Claire, Vo, Dang-Nghiem, Belkahla, Sana, Orecchioni, Stefania, Talarico, Giovanna, Bertolini, Francesco, Bozic, Milica, Valdivielso, Jose M., Bejjani, Fabienne, Jariel, Isabelle, Lopez-Mejia, Isabel C., Fajas, Lluis, Lecellier, Charles-Henri, Hernandez, Javier, Daujat, Martine, Villalba, Martin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587676/
https://ncbi.nlm.nih.gov/pubmed/28878225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10339-5
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