The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

Controlling cholesterol levels is a major challenge in human health, since hypercholesterolemia can lead to serious cardiovascular disease. Drugs that target carbohydrate metabolism can also modify lipid metabolism and hence cholesterol plasma levels. In this sense, dichloroacetate (DCA), a pyruvate...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Khan, Abrar Ul Haq, Allende-Vega, Nerea, Gitenay, Delphine, Gerbal-Chaloin, Sabine, Gondeau, Claire, Vo, Dang-Nghiem, Belkahla, Sana, Orecchioni, Stefania, Talarico, Giovanna, Bertolini, Francesco, Bozic, Milica, Valdivielso, Jose M., Bejjani, Fabienne, Jariel, Isabelle, Lopez-Mejia, Isabel C., Fajas, Lluis, Lecellier, Charles-Henri, Hernandez, Javier, Daujat, Martine, Villalba, Martin
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587676/
https://ncbi.nlm.nih.gov/pubmed/28878225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10339-5
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