Efficacy of Cefiderocol against Carbapenem-Resistant Gram-Negative Bacilli in Immunocompetent-Rat Respiratory Tract Infection Models Recreating Human Plasma Pharmacokinetics

Cefiderocol (S-649266), a novel siderophore cephalosporin, shows potent activity against carbapenem-resistant Gram-negative bacilli. In this study, we evaluated the efficacy of cefiderocol against carbapenem-resistant Gram-negative bacilli (Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsi...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Matsumoto, Shuhei, Singley, Christine M., Hoover, Jennifer, Nakamura, Rio, Echols, Roger, Rittenhouse, Stephen, Tsuji, Masakatsu, Yamano, Yoshinori
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571323/
https://ncbi.nlm.nih.gov/pubmed/28630178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00700-17
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