Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization

Macrophages are key cell types of the innate immune system regulating host defense, inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and often opposing phenotypes are displayed which are dictated by environmental clues and depend on highly plastic transcriptional...

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Publicat a:PLoS One
Autors principals: Surdziel, Ewa, Clay, Ieuan, Nigsch, Florian, Thiemeyer, Anke, Allard, Cyril, Hoffman, Gregory, Reece-Hoyes, John S., Phadke, Tanushree, Gambert, Romain, Keller, Caroline Gubser, Ludwig, Marie-Gabrielle, Baumgarten, Birgit, Frederiksen, Mathias, Schübeler, Dirk, Seuwen, Klaus, Bouwmeester, Tewis, Fodor, Barna D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570424/
https://ncbi.nlm.nih.gov/pubmed/28837623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183679
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