Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from Mycobacterium tuberculosis proceeds through a catalytic shunt pathway

CYP121, the cytochrome P450 enzyme in Mycobacterium tuberculosis that catalyzes a single intramolecular C–C cross-linking reaction in the biosynthesis of mycocyclosin, is crucial for the viability of this pathogen. This C–C coupling reaction represents an expansion of the activities carried out by P...

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Vydáno v:J Biol Chem
Hlavní autoři: Dornevil, Kednerlin, Davis, Ian, Fielding, Andrew J., Terrell, James R., Ma, Li, Liu, Aimin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569305/
https://ncbi.nlm.nih.gov/pubmed/28667013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794099
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