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Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression

Methyltransferase DNMT2 is suggested to be involved in the regulation of numerous processes, however its biological significance and underlying molecular mechanisms remain elusive. In the present study, we have used WI-38 and BJ human fibroblasts as an in vitro model system to investigate the effect...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Lewinska, Anna, Adamczyk-Grochala, Jagoda, Kwasniewicz, Ewa, Deregowska, Anna, Semik, Ewelina, Zabek, Tomasz, Wnuk, Maciej
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568885/
https://ncbi.nlm.nih.gov/pubmed/28843151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.08.012
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