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Transmembrane allosteric energetics characterization for strong coupling between proton and potassium ion binding in the KcsA channel
The slow spontaneous inactivation of potassium channels exhibits classic signatures of transmembrane allostery. A variety of data support a model in which the loss of K(+) ions from the selectivity filter is a major factor in promoting inactivation, which defeats transmission, and is allosterically...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5565416/ https://ncbi.nlm.nih.gov/pubmed/28768808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701330114 |
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