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Antibody blood-brain barrier efflux is modulated by glycan modification
BACKGROUND: Drug delivery to the brain is a major roadblock to treatment of Alzheimer’s Disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer’s treatment outcomes. New approaches are needed to better accomplish this goal. Based on...
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| Veröffentlicht in: | Biochim Biophys Acta |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5557653/ https://ncbi.nlm.nih.gov/pubmed/28624473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.06.008 |
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