Antibody blood-brain barrier efflux is modulated by glycan modification

BACKGROUND: Drug delivery to the brain is a major roadblock to treatment of Alzheimer’s Disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer’s treatment outcomes. New approaches are needed to better accomplish this goal. Based on...

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Udgivet i:Biochim Biophys Acta
Main Authors: Finke, John M., Ayres, Kari R., Brisbin, Ryan P., Hill, Hali A., Wing, Emily E., Banks, William A.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557653/
https://ncbi.nlm.nih.gov/pubmed/28624473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.06.008
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