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Successful metformin treatment of insulin resistance is associated with down-regulation of the kynurenine pathway

CONTEXT: An extensive body of literature indicates a relationship between insulin resistance and the up-regulation of the kynurenine pathway, i.e. the preferential conversion of tryptophan to kynurenine, with subsequent overproduction of diabetogenic downstream metabolites, such as kynurenic acid. C...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Muzik, Otto, Burghardt, Paul, Yi, Zhengping, Kumar, Ajay, Seyoum, Berhane
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554450/
https://ncbi.nlm.nih.gov/pubmed/28478038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.04.155
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