B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals

Lipid dysregulation is a common hepatic adverse outcome after exposure to toxic drugs and chemicals. A donor-free rat hepatocyte-like (B-13/H) cell was therefore examined as an in vitro model for investigating mechanisms. The B-13/H cell irreversibly accumulated triglycerides (steatosis) in a time-...

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Detalhes bibliográficos
Publicado no:Toxicology
Main Authors: Leitch, Alistair C., Probert, Philip M.E., Shayman, James A., Meyer, Stephanie K., Kass, George E.N., Wright, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553091/
https://ncbi.nlm.nih.gov/pubmed/28552552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2017.05.014
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