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Effects of Acyclovir, Foscarnet and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA()
We examined the impact of two clinically approved anti-herpes drugs, acyclovir and Forscarnet (phosphonoformate) on the exonuclease activity of the herpes simplex virus-1 DNA polymerase, UL30. Acyclovir triphosphate and Foscarnet, along with the closely related phosphonoacetic acid, did not affect e...
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| Publicado no: | Biochemistry |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5551684/ https://ncbi.nlm.nih.gov/pubmed/26836009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00065 |
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