Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer

Resistance to cisplatin (DDP) and dose-related toxicity remain two important obstacles in the treatment of prostate cancer (PCa) patients with DDP-based chemotherapy. We have investigated whether the knockdown of hypoxia-inducible factor-1 alpha (HIF-1α) by siRNA could enhance the antitumor activity...

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Vydáno v:Sci Rep
Hlavní autoři: Gu, Junlian, Li, Yang, Zeng, Jun, Wang, Bo, Ji, Kun, Tang, Yufeng, Sun, Qing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548753/
https://ncbi.nlm.nih.gov/pubmed/28790395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07973-4
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