Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?

BACKGROUND: Sepsis is defined as a dysregulated immune response to infection. Impaired immune response in sepsis, often described as endotoxin tolerance, is characterized by unresponsiveness of monocytes on lipopolysaccharide (LPS) stimulation to release tumor necrosis factor α (TNFα). Furthermore,...

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Veröffentlicht in:PLoS One
Hauptverfasser: Winkler, Martin Sebastian, Rissiek, Anne, Priefler, Marion, Schwedhelm, Edzard, Robbe, Linda, Bauer, Antonia, Zahrte, Corinne, Zoellner, Christian, Kluge, Stefan, Nierhaus, Axel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542660/
https://ncbi.nlm.nih.gov/pubmed/28771573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182427
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