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Toward High-Throughput Predictive Modeling of Protein Binding/Unbinding Kinetics
One of the unaddressed challenges in drug discovery is that drug potency determined in vitro is not a reliable indicator of drug activity in vivo. Accumulated evidence suggests that in vivo activity is more strongly correlated with the binding/unbinding kinetics than the equilibrium thermodynamics o...
Zapisane w:
| Wydane w: | J Chem Inf Model |
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| Główni autorzy: | , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2016
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5537004/ https://ncbi.nlm.nih.gov/pubmed/27159844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.5b00632 |
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