Combination of novel HER2‐targeting antibody 1E11 with trastuzumab shows synergistic antitumor activity in HER2‐positive gastric cancer

The synergistic interaction of two antibodies targeting the same protein could be developed as an effective anti‐cancer therapy. Human epidermal growth factor receptor 2 (HER2) is overexpressed in 20–25% of breast and gastric cancer patients, and HER2‐targeted antibody therapy using trastuzumab is e...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Ko, Bong-Kook, Lee, Sook-Yeon, Lee, Young-Ha, Hwang, In-Sik, Persson, Helena, Rockberg, Johan, Borrebaeck, Carl, Park, Dongeun, Kim, Kyu-Tae, Uhlen, Mathias, Lee, Jong-Seo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528653/
https://ncbi.nlm.nih.gov/pubmed/25306393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.09.007
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