Combination of novel HER2‐targeting antibody 1E11 with trastuzumab shows synergistic antitumor activity in HER2‐positive gastric cancer

The synergistic interaction of two antibodies targeting the same protein could be developed as an effective anti‐cancer therapy. Human epidermal growth factor receptor 2 (HER2) is overexpressed in 20–25% of breast and gastric cancer patients, and HER2‐targeted antibody therapy using trastuzumab is e...

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Vydáno v:Mol Oncol
Hlavní autoři: Ko, Bong-Kook, Lee, Sook-Yeon, Lee, Young-Ha, Hwang, In-Sik, Persson, Helena, Rockberg, Johan, Borrebaeck, Carl, Park, Dongeun, Kim, Kyu-Tae, Uhlen, Mathias, Lee, Jong-Seo
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2014
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528653/
https://ncbi.nlm.nih.gov/pubmed/25306393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.09.007
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