Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity

Cancer cells may use PARP enzymes and Homologous Recombination to repair single and double strand breaks caused by genotoxic insults. In this study, the PARP‐1 inhibitor Rucaparib was utilized to increase the sensitivity to chemoradiotherapy treatment in BRCA‐2‐deficient and ‐proficient pancreatic c...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Porcelli, Letizia, Quatrale, Anna E., Mantuano, Paola, Leo, Maria G., Silvestris, Nicola, Rolland, Jean F., Carioggia, Enza, Lioce, Marco, Paradiso, Angelo, Azzariti, Amalia
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2012
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528465/
https://ncbi.nlm.nih.gov/pubmed/23148997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.10.002
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