Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression

Glomerular basement membrane (GBM) damage plays a pivotal role in pathogenesis of albuminuria in diabetic nephropathy (DN). Heparan sulfate (HS) degradation induced by podocyte heparanase is the major cause of GBM thickening and abnormal perm-selectivity. In the present study, we aimed to examine th...

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Veröffentlicht in:Sci Rep
Hauptverfasser: An, Xiaofei, Zhang, Lin, Yuan, Yanggang, Wang, Bin, Yao, Qiuming, Li, Ling, Zhang, Jisheng, He, Ming, Zhang, Jinan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527129/
https://ncbi.nlm.nih.gov/pubmed/28743882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06844-2
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