Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion

Neurotransmission and secretion of hormones involve a sequence of protein/lipid interactions with lipid turnover impacting on vesicle trafficking and ultimately fusion of secretory vesicles with the plasma membrane. We previously demonstrated that sphingosine, a sphingolipid metabolite, promotes for...

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Foilsithe in:Sci Rep
Main Authors: Darios, Frederic D., Jorgacevski, Jernej, Flašker, Ajda, Zorec, Robert, García-Martinez, Virginia, Villanueva, José, Gutiérrez, Luis M., Leese, Charlotte, Bal, Manjot, Nosyreva, Elena, Kavalali, Ege T., Davletov, Bazbek
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519734/
https://ncbi.nlm.nih.gov/pubmed/28729700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05948-z
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