Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

BACKGROUND: Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunits p110γ and p110δ of PI3Kγ and PI3Kδ in p110γ/δ(−/−) mice leads to defective B-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Commun Signal
Egile Nagusiak: Bucher, Kirsten, Schmitt, Fee, Mothes, Benedikt, Blumendeller, Carolin, Schäll, Daniel, Piekorz, Roland, Hirsch, Emilio, Nürnberg, Bernd, Beer-Hammer, Sandra
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518148/
https://ncbi.nlm.nih.gov/pubmed/28724384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-017-0185-y
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