Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells

The R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs) comprises PTPRZ and PTPRG. A recent study on primary human glioblastomas suggested a close association between PTPRZ1 (human PTPRZ) expression and cancer stemness. However, the functional roles of PTPRZ activity in glioma stem c...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Fujikawa, Akihiro, Sugawara, Hajime, Tanaka, Taisaku, Matsumoto, Masahito, Kuboyama, Kazuya, Suzuki, Ryoko, Tanga, Naomi, Ogata, Atsuto, Masumura, Makoto, Noda, Masaharu
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514153/
https://ncbi.nlm.nih.gov/pubmed/28717188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05931-8
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