Pyrrolidine dithiocarbamate ameliorates endothelial dysfunction in thoracic aorta of diabetic rats by preserving vascular DDAH activity

OBJECTIVE: Endothelial dysfunction plays a pivotal role in the development of diabetic cardiovascular complications. Accumulation of endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) and inhibition of dimethylarginine dimethylaminohydrolase (DDAH) activity have been...

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Bibliographic Details
Published in:PLoS One
Main Authors: Lu, Chang-Wu, Lin, Yuan, Lei, Yan-Ping, Wang, Lan, He, Zhi-Min, Xiong, Yan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513417/
https://ncbi.nlm.nih.gov/pubmed/28715444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179908
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