Sensing of HIV-1 Entry Triggers a Type I Interferon Response in Human Primary Macrophages

Along with CD4(+) T lymphocytes, macrophages are a major cellular source of HIV-1 replication and a potential viral reservoir. Following entry and reverse transcription in macrophages, cloaking of the viral cDNA by the HIV-1 capsid limits its cytosolic detection, enabling efficient replication. Howe...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Decalf, Jérémie, Desdouits, Marion, Rodrigues, Vasco, Gobert, François-Xavier, Gentili, Matteo, Marques-Ladeira, Santy, Chamontin, Célia, Mougel, Marylène, Cunha de Alencar, Bruna, Benaroch, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512232/
https://ncbi.nlm.nih.gov/pubmed/28490595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00147-17
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