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Differential chromatin profiles partially determine transcription factor binding

We characterize how genomic variants that alter chromatin accessibility influence regulatory factor binding with a new method called DeltaBind that predicts condition specific factor binding more accurately than other methods based on DNase-seq data. Using DeltaBind and DNase-seq experiments we pred...

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Publicat a:PLoS One
Autors principals: Chen, Rujian, Gifford, David K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509100/
https://ncbi.nlm.nih.gov/pubmed/28704389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179411
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