Causal assessment of serum urate levels in cardiometabolic diseases through a Mendelian Randomization study

BACKGROUND: Although epidemiological studies have reported positive associations between circulating urate levels and cardiometabolic diseases, causality remains uncertain. OBJECTIVE: Through a Mendelian randomization approach, we assessed whether serum urate levels are causally relevant in type-2 d...

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Publicat a:J Am Coll Cardiol
Autors principals: Keenan, Tanya, Zhao, Wei, Rasheed, Asif, Ho, Weang K., Malik, Rainer, Felix, Janine F, Young, Robin, Shah, Nabi, Samuel, Maria, Sheikh, Nasir, Mucksavage, Megan L., Shah, Omar, Li, Jin, Morley, Michael, Laser, Annika, Mallick, Nadeem Hayat, Zaman, Khan Shah, Ishaq, Mohammad, Rasheed, Syed Zahed, Memon, Fazal-ur-Rehman, Ahmed, Faisal, Hanif, Bashir, Lakhani, Muhammad Shakir, Fahim, Muhammad, Ishaq, Madiha, Shardha, Naresh Kumar, Ahmed, Naveeduddin, Mahmood, Khalid, Iqbal, Waseem, Akhtar, Saba, Raheel, Rabia, O’Donnell, Christopher J., Hengstenberg, Christian, Marz, Winifred, Kathiresan, Sekar, Samani, Nilesh, Goel, Anuj, Hopewell, Jemma C, Chambers, John, Cheng, Yu-Ching, Sharma, Pankaj, Yang, Qiong, Rosand, Jonathan, Boncoraglio, Giorgio B., Kazmi, Shahana Urooj, Hakonarson, Hakon, Köttgen, Anna, Kalogeropoulos, Andreas, Frossard, Philippe, Kamal, Ayeesha, Dichgans, Martin, Cappola, Thomas, Reilly, Muredach P., Danesh, John, Rader, Daniel J., Voight, Benjamin F., Saleheen, Danish
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503188/
https://ncbi.nlm.nih.gov/pubmed/26821629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2015.10.086
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