Alpha 2 Na(+),K(+)-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells

Ouabain (OUA) is a cardiac glycoside that binds to Na(+),K(+)-ATPase (NKA), a conserved membrane protein that controls cell transmembrane ionic concentrations and requires ATP hydrolysis. At nM concentrations, OUA activates signaling pathways that are not related to its typical inhibitory effect on...

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Published in:Sci Rep
Main Authors: Kinoshita, Paula F., Yshii, Lidia M., Orellana, Ana Maria M., Paixão, Amanda G., Vasconcelos, Andrea R., Lima, Larissa de Sá, Kawamoto, Elisa M., Scavone, Cristoforo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501845/
https://ncbi.nlm.nih.gov/pubmed/28687727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05075-9
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