Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

Sjögren’s syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debilitating fatigue. Dysregulation of type I interferon...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:PLoS Genet
المؤلفون الرئيسيون: Li, He, Reksten, Tove Ragna, Ice, John A., Kelly, Jennifer A., Adrianto, Indra, Rasmussen, Astrid, Wang, Shaofeng, He, Bo, Grundahl, Kiely M., Glenn, Stuart B., Miceli-Richard, Corinne, Bowman, Simon, Lester, Sue, Eriksson, Per, Eloranta, Maija-Leena, Brun, Johan G., Gøransson, Lasse G., Harboe, Erna, Guthridge, Joel M., Kaufman, Kenneth M., Kvarnström, Marika, Cunninghame Graham, Deborah S., Patel, Ketan, Adler, Adam J., Farris, A. Darise, Brennan, Michael T., Chodosh, James, Gopalakrishnan, Rajaram, Weisman, Michael H., Venuturupalli, Swamy, Wallace, Daniel J., Hefner, Kimberly S., Houston, Glen D., Huang, Andrew J. W., Hughes, Pamela J., Lewis, David M., Radfar, Lida, Vista, Evan S., Edgar, Contessa E., Rohrer, Michael D., Stone, Donald U., Vyse, Timothy J., Harley, John B., Gaffney, Patrick M., James, Judith A., Turner, Sean, Alevizos, Ilias, Anaya, Juan-Manuel, Rhodus, Nelson L., Segal, Barbara M., Montgomery, Courtney G., Scofield, R. Hal, Kovats, Susan, Mariette, Xavier, Rönnblom, Lars, Witte, Torsten, Rischmueller, Maureen, Wahren-Herlenius, Marie, Omdal, Roald, Jonsson, Roland, Ng, Wan-Fai, Nordmark, Gunnel, Lessard, Christopher J., Sivils, Kathy L.
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2017
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501660/
https://ncbi.nlm.nih.gov/pubmed/28640813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006820
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